MLL: Deep insight
نویسندگان
چکیده
منابع مشابه
Deep Insight Section
Spinophilin is a scaffolding protein with modular domains that govern its interaction with a large number of cellular proteins. The Spinophilin gene locus is localized at chromosome 17q21, a chromosomal region frequently affected by genomic instability in different human tumours. The scaffolding protein interacts with the tumour-suppressor ARF which has suggested a role for Spinophilin in cell ...
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During cell division the genome is duplicated and segregated along with organelles into the daughter cells with high fidelity. The physical separation of the two daughter cells topologically resembles virus budding and multivesicular endosome (MVE) formation in the sense that they all involve outward budding from cytosol. According to the crucial role of the Endosomal Sorting Complex Required f...
متن کاملDeep Insight Section
Eukaryote chromosomes usually condense during mitosis. Chromosome condensation is strictly regulated by cellular elaborated machinery but the details of the mechanism still remains to be elucidated. Occasionally, chromosomes condense at outside of mitosis under several circumstances (Gotoh et al., 1995; Gotoh and Durante, 2006). This phenomenon is known as premature chromosome condensation (PCC...
متن کاملDeep Insight Section
IL-17-producing CD4 T cells (Th17 cells) are understood to be a distinct lineage of CD4 T helper (Th) cells, which play an important role in the host defense, tissue inflammation and autoimmunity. The identification of Th17 cells collapsed the concept of the previously held Th1/Th2 paradigm in infection and autoimmunity. Recent studies have provided new information on the role of Th17 cells in ...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38034